Melatonin is a molecule produced from the amino acid tryptophan. It’s created by almost all living organisms. In the man, it’s secreted out of the pineal gland that is a little pea sized gland placed in the middle of the human brain. This particular gland is outside the blood brain barrier and thus melatonin køb has the ability to go into the circulation quickly. Melatonin is a hormone as well as the target cells are placed in the mind and since it’s a hormone, the biological actions of its are experienced just when melatonin binds to certain receptors.
Melatonin is discharged from the gastrointestinal tract, lymphocytes, retina, bone marrow cells as well as epithelial cells. Nevertheless, the melatonin from these cells functions like a paracrine hormone (acting on close by cells) and also does not have any impact on the human brain.